Exhibit 23 Consent of Independent Registered Public Accounting Firm To the Trustees of Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan We consent to incorporation of our report dated June 23, 2006 relating to the statements of net assets available for plan benefits of the Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan as of December 31, 2005 and 2004 and the related statement of changes in net assets available for plan benefits for the year ended December 31, 2005; in the December 31, 2005 annual report on Form 11-K of Enzo Biochem, Inc. Marks Paneth & Shron LLP Woodbury, NY June 23, 2003