FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Perlysky Dov
   2. Issuer Name and Ticker or Trading Symbol
ENZO BIOCHEM INC [ENZ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O ENZO BIOCHEM, INC., 527 MADISON AVENUE		 3. Date of Earliest Transaction (Month/Day/Year)
10/18/2018
(Street)

NEW YORK, NY 10022		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/18/2018   P   10,000 A $ 3.5 266,235 (1) D  
Common Stock               523,457 I See footnotes (2) (3) (4) (5) (6) (7)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Perlysky Dov
C/O ENZO BIOCHEM, INC.
527 MADISON AVENUE
NEW YORK, NY 10022		   X      

Signatures

 /s/ Dov Perlysky   10/22/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes 218,816 vested options.
(2) Includes 45,000 Common Stock owned by Sky Ventures LLC, whose manager is Dov Perlysky and of which Dov Perlysky disclaims beneficial ownership.
(3) Includes 109,237 Common Stock owned by RSD 2010 Enzo GRAT, whose trustee is Dov Perlysky and of which Dov Perlysky disclaims beneficial ownership.
(4) Includes 325,875 Common Stock held by Kinder Investment LP, an entity of which Dov Perlysky is the Managing Member of the General Partner and of which Dov Perlysky disclaims beneficial ownership.
(5) Includes 6,981 Common Stock held by Krovim LLC, an entity of which Dov Perlysky is the Managing Member of the General Partner, and children of Dov Perlysky own a 27.54% interest, and of which Dov Perlysky disclaims beneficial ownership.
(6) Includes 3,225 Common Stock held by MidAtlantic Capital Lending LLC, an entity of which Dov Perlysky owns 1% and of which Dov Perlysky disclaims beneficial ownership.
(7) Includes 33,139 Common Stock held by Laya Perlysky, of which Dov Perlysky disclaims beneficial ownership and of which Dov Perlysky disclaims beneficial ownership.

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