EXHIBIT 10(bb) ENZO DIAGNOSTICS, INC. - BAXTER HEALTHCARE CORPORATION, SCIENTIFIC PRODUCTS AND LIFESCIENCES DIVISION DISTRIBUTORSHIP AGREEMENT THIS AGREEMENT, effective upon acceptance by both parties below by and between ENZO DIAGNOSTICS, INC. ("ENZO"), a New York corporation having its principal place of business at 60 Executive Boulevard, Farmingdale, New York 11735, and the Scientific Products, Industrial and Lifesciences division of Baxter Healthcare Corporation ("BAXTER") a Delaware Corporation having its principal place of business at 1430 Waukegan Road, McGaw Park, Illinois 60085. WHEREAS, ENZO owns rights to certain PATENTS listed in EXHIBIT A ("PATENTS"); WHEREAS ENZO manufactures and/or sells certain products covered by claims of PATENTS which products are listed in EXHIBIT B hereto ("PRODUCTS"); WHEREAS BAXTER wishes to market and distribute some of said PRODUCTS on a nonexclusive basis in accordance with the terms and conditions of this Agreement; NOW, THEREFORE, in consideration of the good and valuable mutual agreements hereinafter set forth, the parties hereto agree as follows: 1. Distributor Appointment ENZO hereby appoints BAXTER to act as its nonexclusive distributor worldwide for the distribution and sale of PRODUCTS (EXHIBIT B), and BAXTER agrees to act as such distributor under the terms and conditions set forth herein. BAXTER agrees: a. not to purchase any PRODUCTS from other suppliers; b. not to manufacture PRODUCTS; c. to rely on ENZO as its sole source of PRODUCTS; d. not to use any PRODUCT to manufacture new or other PRODUCTS; e. that all PRODUCTS distributed by BAXTER are for research use only and are not intended for or to be used for diagnostic or therapeutic purposes; and f. that except for DISTRIBUTION under the terms and conditions as set forth in this AGREEMENT, purchase does not include any right or license to exploit these PRODUCTS commercially, including any right to sell these PRODUCTS to other distributors and that any other commercial use or development of these PRODUCTS without the express written authorization of ENZO is strictly prohibited. Nothing herein creates or constitutes a partnership or an agreement of agency between the parties with respect to any activities whatsoever. The relationship between ENZO and BAXTER shall be that of seller and buyer, and neither party shall conclude any contract or agreement or make any commitment, representation or warranty which binds the other party or otherwise act in the name of or on behalf of the other party. ENZO and BAXTER agree that the distribution relationship between them does not constitute, nor does it imply, a license of any of ENZO's technology or patents, nor does it abrogate any of ENZO's rights under its patents. ENZO maintains full rights under its PATENTS. The foregoing statements are paramount to this AGREEMENT. 2. PRODUCTS, Price and Payment A list of Enzo's current domestic retail price index is included in EXHIBIT B hereto and incorporated by reference herein. The price to BAXTER for each product shall be * the current domestic retail price as reflected by the price index. Prices to BAXTER may be adjusted no more than once during each calendar year. ENZO has the right to adjust prices to BAXTER after providing BAXTER with forty-five (45) days written notice. Any such price adjustment will affect future purchases only and ENZO agrees to honor BAXTER's - ---------- * The information omitted is confidential and has been filed separately with the Commission pursuant to Rule 24b-2. - 2 - existing purchase orders on the effective date of such price adjustment at the prices in effect prior to such effective date. ENZO or BAXTER may propose in writing to delete PRODUCT in EXHIBIT B. ENZO or BAXTER may propose to add PRODUCT or products to EXHIBIT B. Both partners must agree in writing to such additions before such changes are incorporated therein. 3. Distributor Duties BAXTER shall: a. submit its orders for the PRODUCTS on its standard purchase order form. To the extent that the terms and conditions of BAXTER's standard purchase order form are inconsistent with the terms and conditions of this Agreement, the terms and conditions of this Agreement shall govern; b. pay for all such orders within thirty (30) days of the invoice date for such order; c. advertise and promote the PRODUCTS by methods which in BAXTER's judgment are best suited for the sale of such PRODUCTS; 4. Supplier's Duties ENZO shall: a. promptly ship to all BAXTER distribution centers in accordance with the shipping instructions (compatible with ENZO's shipping policy and PRODUCT stability) specified in BAXTER's purchase orders, collect, F.O.B. origin, with carrier to bill third party freight charges to Baxter Healthcare Corporation, Scientific Products freight payment, P.O.Box 815, Deerfield, Illinois 60015. All direct (drop) shipments to BAXTER's customers by ENZO shall be F.O.B. destination, Prepaid and Add. Baxter reserves the right to determine the carriers to be selected for shipment to its customers (compatible with ENZO's shipping policy and PRODUCT stability); -3- b. adequately package and deliver the PRODUCTS, using those references to and trademarks of BAXTER as BAXTER shall specify in writing; c. execute and comply with the provisions of BAXTER's Continuing Guaranty, a copy of which is attached hereto as EXHIBIT C. 5. Forecasts and Purchase Orders for BAXTER Inventory BAXTER shall issue a forecast schedule by the end of the mid-month of each calendar quarter covering its estimated requirements for PRODUCTS for the succeeding two (2) calendar quarters. Such forecast shall be considered for planning purposes only and not in any way be considered a purchase commitment. A purchase order will be issued by BAXTER at least sixty (60) days in advance of the requested delivery of PRODUCT. This purchase order will indicate specific delivery and/or shipping requirements. Purchase orders will be delivered to ENZO by Federal Express or similar carrier so that the receipt can be confirmed. Orders placed with ENZO may not be canceled by BAXTER more than (15) fifteen days after issuance of order. ENZO shall meet such requirements unless it advises BAXTER within fifteen (15) days of the date of such purchase order that it is unable to supply PRODUCT as ordered by BAXTER whereupon the parties agree to discuss a revised schedule for delivery of PRODUCT to BAXTER. After ENZO and BAXTER agree to the provisions of a revised schedule, ENZO will make its best efforts to fulfill the provisions of the revised schedule. 6. PRODUCT Deliveries and Specifications for BAXTER Inventory Within thirty (30) days after the effective date of this Agreement, ENZO shall provide BAXTER with PRODUCT specifications and package inserts for those PRODUCTS in EXHIBIT B that BAXTER intends to distribute. When an order is placed by BAXTER for its inventory ENZO shall ship the PRODUCT in accordance with Section 4 above. ENZO shall supply, at the time of shipment of the PRODUCT to BAXTER a statement that the PRODUCT conforms to the PRODUCT specifications. If after receipt of the PRODUCT BAXTER determines that it does not conform to the PRODUCT -4- specification provided by ENZO, and that the failure to conform to the PRODUCT specifications was not the direct result of shipping and handling, BAXTER will provide ENZO with documentation of this failure to conform to the PRODUCT specifications. If ENZO accepts the documentation provided by BAXTER ENZO will ship a replacement order. If ENZO does not accept the documentation provided by BAXTER then the differences in the determination of the manufacturing specifications for the allegedly nonconforming PRODUCT will be settled by representatives of the technical staffs of ENZO and BAXTER. 7. Patents and Trademarks a. Patents ENZO shall defend, indemnify and hold harmless BAXTER from and against any liability arising out of a claim of patent infringement with respect to any of the PRODUCTS. If BAXTER receives a notice from a third party asserting that any of the PRODUCTS of this AGREEMENT infringe on an issued patent in the country of sale, then BAXTER shall immediately give written notice to ENZO. Upon notice to ENZO or BAXTER from a third party asserting that any of the PRODUCTS of this AGREEMENT infringe on an issued patent in the country in which such PRODUCTS are sold, ENZO has the right to exclude such PRODUCTS from this AGREEMENT for that country and can further by written notice instruct BAXTER to cease all such distribution of such PRODUCT in that country. Further distribution of PRODUCTS after such instruction from ENZO to BAXTER will be at the sole risk of BAXTER and BAXTER shall indemnify and hold harmless ENZO from all infringement liability and damages with respect to further distribution of such PRODUCTS, including legal costs and attorneys fees. Notwithstanding any third party infringement claims, all provisions of this AGREEMENT, including Section 6, shall not be affected but shall remain in full force and effect to the fullest extent possible. ENZO agrees to repurchase from BAXTER, at a price equivalent to the full purchase price paid by BAXTER any quantity of PRODUCT in BAXTER's inventory which BAXTER (i) has been instructed by ENZO to discontinue the sale of such PRODUCT, or (ii) reasonably believes it should or cannot sell, based upon an opinion of BAXTER's counsel that future sales by BAXTER may result in patent infringement, or -5- because of a decision, whether interlocutory or final, rendered in any patent infringement action. b. Trademarks ENZO recognizes that BAXTER is the owner of the trademarks and trade names connoting BAXTER which it may elect to use in the promotion and sale of the PRODUCTS and that ENZO has no ownership or other rights or interests in such trademarks and trade names. BAXTER recognizes that ENZO is the owner of the trademarks and trade names connoting ENZO and ENZO's PRODUCTS which it may elect to use in the promotion and sale of the PRODUCTS and that BAXTER has no ownership or other rights or interests in such trademarks and trade names. 8. Sales Promotions BAXTER shall use its best efforts in sales promotions and advertisement of the PRODUCTS such as individual client contact, direct mailings, catalog listings and trade meeting promotions. ENZO will provide BAXTER with one (1) copy of the literature, technical data, specifications and the like describing the PRODUCTS that BAXTER is distributing as they are currently produced for the assistance of BAXTER in the preparation of advertising, catalog and other sales and promotional material. BAXTER shall use its best efforts to list PRODUCTS in its future published product catalog(s) in which the PRODUCTS can be listed after the effective date of this AGREEMENT. 9. PRODUCT Warranty In addition to all other warranties given by ENZO in this AGREEMENT and the exhibits hereto or otherwise, ENZO warrants that the PRODUCTS will conform to the specifications and samples provided by ENZO for such PRODUCTS; will be free from defects in design, materials and workmanship and are merchantable and fit for their intended purposes. ENZO's sole obligation is to replace the PRODUCTS with similar PRODUCTS to the extent of the purchase price. THIS WARRANTY IS EXPRESSLY IN LIEU OF ANY OTHER WARRANTIES OR LIABILITIES, EXPRESS OR IMPLIED, INCLUDING THE WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. -6- 10. Storage and Stock Rotation ENZO agrees to share with BAXTER all necessary storage and stock rotation practices which apply to the PRODUCTS. BAXTER further agrees to take diligent care not to ship PRODUCTS to its customers which have expired, been damaged in storage or handling, or improperly stored. BAXTER will be responsible for damages arising from its shipment of expired, damaged, or improperly stored PRODUCTS. 11. Confidentiality of Information BAXTER and ENZO agree that they will not disclose any proprietary and confidential information made available to them by the other party. Both parties further agree that all confidential material will be in writing and marked confidential and that they will not make more copies that necessary of documents or materials which are provided under this AGREEMENT, nor will they distribute such documents or materials, or copies thereof, to any third party. Furthermore, both parties agree to return any such documents or materials, or copies thereof, which are provided under this AGREEMENT if directed or requested to do so. The above obligations shall not apply to those portions of ENZO's and BAXTER's proprietary and confidential information which (1) are or become generally publicly available through no act or failure to act by the recipient party, (2) were demonstrably known to the other party prior to disclosure under this AGREEMENTS, or (3) are subsequently disclosed by a third party having a legal right to do so and not having a confidential relationship with respect thereto. 12. Force Majeure No liability shall result to either party from delay in performance or from nonperformance under this Agreement caused by circumstances beyond the reasonable control of the party who has delayed performance or not performed. The nonperforming party shall be diligent in attempting to remove any such cause and shall promptly notify the other party of its extent and probable duration. -7- 13. Duration and Termination This AGREEMENT shall become effective as of the date hereinabove written and shall continue for a period of three (3) years. Unless terminated, it will continue thereafter for successive renewal terms of one (1) year each. Either party may terminate this AGREEMENT without cause at any time by giving the other party notice in writing at least six (6) months in advance of the effective termination date stated in such notice. Each party may also terminate this AGREEMENT upon thirty (30) days prior written notice to the other party for a material breach by the other party of any of the provisions of this AGREEMENT where such breach is not cured within said notice period. Upon termination of this AGREEMENT all distribution rights to BAXTER will be deemed immediately canceled and returned in toto to ENZO. 15. Indemnification Except to the extent the other is negligent or commits an act of wilful misconduct or in default of the terms hereof, each of the parties agrees to indemnify, defend and hold harmless the other party hereto, its successors and assigns, employees and agents, from and against, any and all claims, losses, liabilities, demands, damages, actions, suits, judgments, costs and expenses (including reasonable attorneys' fees), incurred, relating to, caused by or arising out of the breach of any covenant or agreement of such party under this AGREEMENT. 16. Notices All notices, requests, demands and other communications required or permitted to be given hereunder shall be sent by personal delivery; certified mail, return receipt requested; telecopier; or overnight courier to the parties at the addresses set forth below or to such other address as a party shall have previously designated by written notice to the other party hereto in accordance with this section. Such notices shall be deemed given at the time delivered, if delivered personally; five (5) days after the day sent, if sent by certified mail; and one (1) business day after the day sent, if telecopied or sent by overnight courier. -8- ENZO: Enzo Biochem, Inc. 575 Fifth Avenue, 18th Floor New York, New York 10017 Attn: Dr. Barbara E. Thalenfeld Vice President, Corporate Development Fax No.: (212) 856-0878 BAXTER: BAXTER Healthcare Corporation 1430 Waukegan Road McGaw Park, IL 60085 Attn: Ms. Casey Rooney Fax No. (708) 473-3971 17. Governing Law This Agreement shall be governed, construed and enforced in accordance with the internal laws of the State of New York, including the Uniform Commercial Code as enacted in that jurisdiction, without giving effect to any choice of law rules which may direct the application of the laws of another jurisdiction. 18. Waiver Any terms and conditions of this AGREEMENT may be waived at any time by the party or parties entitled to the benefit thereof but only by a written notice signed by the party or parties waiving such term or condition. Waiver by ENZO or BAXTER of any provision of this AGREEMENT shall not be deemed a waiver of future compliance therewith and such provision as well as all other provisions hereunder shall remain in full force and effect. 19. Compliance with Laws Each party will comply with all United States laws, ordinances and regulations properly applicable to the manufacture, sale and distribution of the PRODUCTS described herein. Where applicable, the parties will comply with the laws of the country in which the product is being sold. 20. Headings All Headings of the clauses of this AGREEMENT are inserted for convenience only and shall not affect any construction or interpretation of this AGREEMENT. -9- 21. Severability In the event that any clause of this Agreement shall be found to be void or unenforceable, such finding shall not be construed to render any other clause of this AGREEMENT either void or unenforceable, and all other clauses shall remain in full force and effect unless the clause(s) which is/are invalid or unenforceable shall substantially affect the rights or obligations granted to or undertaken by either party. 22. Assignment This AGREEMENT may not be assigned by either party without the prior written consent of the other party hereto, provided that BAXTER may assign this AGREEMENT to any purchaser of all or substantially all of the assets of the Sellers' Scientific Products, Industrial and Lifesciences division. Any assignment which does not comply with the foregoing shall be null and void. 23. Counterparts This AGREEMENT may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 22. Entire Agreement This AGREEMENT together with the EXHIBITS attached hereto embodies the entire understanding between the parties hereto with respect to the subject matter hereof, and there are no contracts or prior drafts of the AGREEMENT, understandings, conditions, warranties or representations, oral or written, express or implied, with reference to the subject matter hereof which are not merged herein. Except as otherwise specifically stated, no amendment or modification of this AGREEMENT shall be of any force or effect unless reduced to writing and signed by both parties hereto. -10- IN WITNESS, WHEREOF, the parties have caused this AGREEMENT to be executed by their duly authorized representatives. Enzo Diagnostics, Inc. Baxter Healthcare Corporation Scientific Products, Industrial and Lifesciences Division By:___________________________ By:___________________________ Title: President Title: V.P. Marketing ------------------------ ------------------------ Date: 9/14/95 Date: 9/15/95 ------------------------- ------------------------- * * * * * * * -11- EXHIBIT A Enzo Diagnostics, Inc. Issued Patents
U.S. Patents ====================================================================================================== Patent Number Title/Inventor Issue Date - ------------------------------------------------------------------------------------------------------ 4,687,732 Visualization Polymers and Their Aug. 18, 1987 Application to Diagnostic Medicine David C. Ward et al. - ------------------------------------------------------------------------------------------------------ 4,707,352 Method of Radioactively Labeling Nov. 17, 1987 Diagnostic and Therapeutic Agents Containing a Chelating Group Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,707,440 Nucleic Acid Hybridization Assay and Nov. 17, 1987 Detectable Molecules Useful in Such Assay Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,711,955 Modified Nucleotides and Methods of Dec. 8, 1987 Preparing and Using Same David C. Ward et al. - ------------------------------------------------------------------------------------------------------ 4,746,604 Specific Binding Assays Utilizing A Viable May 24, 1988 Cell as a Label Solomon Mowshowitz - ------------------------------------------------------------------------------------------------------ 4,755,458 Composition and Method for the Detection Jul. 5, 1988 of the Presence of a Polynucleotide Sequence of Interest Elazar Rabbani et al. - ------------------------------------------------------------------------------------------------------ 4,767,609 Therapeutic and Diagnostic Processes Aug. 30, 1988 Using Isotope Transfer to Chelator-Target Recognition Molecule Conjugate Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,772,548 Radioisotopicassay Using Isotope Transfer Sep. 20, 1988 to Chelator-Target Recognition Molecule Conjugate Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,843,122 Detectable Molecules, Method of June 27, 1989 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------
-12- - ------------------------------------------------------------------------------------------------------ 4,849,208 Detectable Molecules, Method of Jul. 18, 1989 Preparation and Use Jannis G. Stavrianopoulos ======================================================================================================
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====================================================================================================== Patent Number Title/Inventor Issue Date - ------------------------------------------------------------------------------------------------------ 4,849,505 Detectable Molecules, Method of Jul. 18, 1989 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,868,103 Analyte Detection by Means of Energy Sep. 19, 1989 Transfer Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,889,798 Heterologous System for the Detection of Dec. 26, 1989 Chemically Labeled DNA and other Biological Materials Providing a Receptor or Target Moiety Thereon Elazar Rabbani - ------------------------------------------------------------------------------------------------------ 4,894,325 Hybridization Method for the Detection of Jan. 16, 1990 Genetic Material Dean Engelhardt et al. - ------------------------------------------------------------------------------------------------------ 4,900,659 Nucleotide Sequence Composition and Feb. 13, 1990 Method for Detection for Neissera Gonorrhoeae and Method for Screening for a Nucleotide Sequence that is Specific for a Genetically Distinct Group Andrew Lo et al. - ------------------------------------------------------------------------------------------------------ 4,943,523 Detectable Molecules, Method of Jul. 24, 1990 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,952,685 Detectable Molecules, Method of Aug. 28, 1990 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 4,987,065 In Vivo Labelling of Polynucleotide Jan. 22, 1991 Sequences Jannis G. Stavrianopoulos et al. - ------------------------------------------------------------------------------------------------------ 4,994,373 Method and Structures Employing Feb. 19, 1991 Chemically-Labelled Polynucleotide Probes Jannis G. Stavrianopoulos et al. - ------------------------------------------------------------------------------------------------------ 5,002,885 Detectable Molecules, Method of Mar. 26, 1991 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 5,013,831 Detectable Molecules, Method of May 7, 1991 Preparation and Use Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------
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- ------------------------------------------------------------------------------------------------------ 5,024,933 Method and Kit for Sample Adherence to June 18, 1991 Test Substrate Huey-Lang Yang et al. - ------------------------------------------------------------------------------------------------------ 5,061,076 Time-Resolved Fluorometer Oct. 29, 1991 Ian Hurley - ------------------------------------------------------------------------------------------------------ 5,082,830 End Labeled Nucleotide Probe Jan. 21, 1992 Christine L. Brakel et al. ======================================================================================================
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====================================================================================================== Patent Number Title/Inventor Issue Date - ------------------------------------------------------------------------------------------------------ 5,175,269 Compound and Detectable Molecules Dec. 29, 1992 Having An Oligo- or Polynucleotide with Modifiable Reactive Group Jannis G. Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 5,241,060 Base Moiety-Labeled Detectable Nucleotide Aug. 31, 1993 Dean Engelhardt et al. - ------------------------------------------------------------------------------------------------------ 5,260,433 Saccharide Specific Binding System Nov. 9, 1993 Labeled Nucleotides Dean Engelhardt et al. - ------------------------------------------------------------------------------------------------------ 5,288,609 Capture Sandwich Hybridization Method Feb. 22, 1994 and Composition Dean Engelhardt et al. - ------------------------------------------------------------------------------------------------------ 5,328,824 Methods of Using Labeled Nucleotides Jul. 12, 1994 7 David C. Ward - ------------------------------------------------------------------------------------------------------ 5,449,767 Modified Polynucleotides and Methods of Sep. 12, 1995 Preparing Same David C. Ward et al. - ------------------------------------------------------------------------------------------------------
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Foreign Patents Granted ====================================================================================================== Patent Number Publication (Country) Title/Inventor Date of Patent Grant - ------------------------------------------------------------------------------------------------------ 560 651 Modified Nucleotides and Methods Oct. 16, 1987 (Australia) of Preparing and Using Same (16 yr. term David C. Ward et al. began Apr. 13, 1982) - ------------------------------------------------------------------------------------------------------ 1 219 824 Modified Nucleotides and Methods Mar. 31, 1987 (Canada) of Preparing and Using Same David C. Ward et al. - ------------------------------------------------------------------------------------------------------ 1 223 831 Modified Nucleotides, Methods of Jul. 7, 1987 (Canada) Preparing and Utilizing and Compositions Containing the Same Dean L. Engelhardt et al. - ------------------------------------------------------------------------------------------------------ EP 0 285 057 B1 Modified Nucleotides, Methods of May 10, 1988 Preparing and Utilizing and Compositions Containing the Same Dean L. Engelhardt et al. - ------------------------------------------------------------------------------------------------------ EP 0 063 879 B1 Modified Nucleotides and Methods Nov. 23, 1989 of Preparing and Using Same David C. Ward et al. - ------------------------------------------------------------------------------------------------------ 1,237,369 Visualization Polymers and Their May 31, 1988 Application to Diagnostic Medicine David C. Ward et al. - ------------------------------------------------------------------------------------------------------ 1,254,525 Kit for Terminally Chemically May 23, 1989 Labeling DNA Christine L. Brakel et al. - ------------------------------------------------------------------------------------------------------ 1,256,023 Method of Radioactively Labeling June 20, 1989 Diagnostic and Therapeutic Agents Containing a Chelating Group Jannis Stavrianopoulos - ------------------------------------------------------------------------------------------------------ 1,260,368 Composition and Method for the Sept. 26, 1989 Detection of the Presence of a Polynucleotide Sequence of Interest Elazar Rabbani et al. - ------------------------------------------------------------------------------------------------------
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- ------------------------------------------------------------------------------------------------------ 1,260,372 Hybridization Method for the Sept. 26, 1989 Detection of Genetic Materials Elazar Rabbani et al. ======================================================================================================
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===================================================================================================== Patent Number Publication (Country) Title/Inventor Date of Patent Grant - ----------------------------------------------------------------------------------------------------- 1,268,115 Method and Composition for April 24, 1990 Detecting Analyte Moieties Solomon Mowshowitz - ----------------------------------------------------------------------------------------------------- 1,281,283 Method for Detecting an Analyte Mar. 12, 1991 (Canada) Moiety by Means of Signal Localization Elazar Rabbani - ----------------------------------------------------------------------------------------------------- 1,285,330 Analyte Detection by Means of June 25, 1991 Energy Transfer Jannis Stavrianopoulos et al. - ----------------------------------------------------------------------------------------------------- 1,288,811 Assay Method Utilizing Nov. 3, 1987 Polynucleotide Sequences Robert Pergolizzi et al. - ----------------------------------------------------------------------------------------------------- EP 0 133 473 B1 In Vivo Labelling of Polynucleotide March 23, Sequences 1994 Jannis Stavrianopoulos et al. - ----------------------------------------------------------------------------------------------------- EP 0 173 339 B1 Composition and Method for the Jan. 22, 1992 Detection of the Presence of a Polynucleotide Sequence of Interest Elazar Rabbani et al. - ----------------------------------------------------------------------------------------------------- EP 0 212 546 B1 Method for Labeling Polynucleotide Apr. 1, 1992 Sequences Jannis Stavrianopoulos et al. - ----------------------------------------------------------------------------------------------------- 1,295,559 Method for Labeling Polynucleotide Feb. 11, 1992 Sequences Jannis Stavrianopoulos et al. - -----------------------------------------------------------------------------------------------------
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- ----------------------------------------------------------------------------------------------------- 1,299,073 Nucleotide Sequence Composition Apr. 21, 1992 Method for Detection of Neisseria (Canada) gonorrhoeae and Method for Screening for a Nucleotide Sequence that is Specific for a Genetically Distinct Group Andrew Lo & Huey-Lang Yang - ----------------------------------------------------------------------------------------------------- 1,309,672 Methods and Structures Employing Nov. 3, 1992 Non-Radioactive Chemically-Labeled Polynucleotide Probes Jannis Stavrianopoulos =====================================================================================================
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===================================================================================================== Patent Number Publication (Country) Title/Inventor Date of Patent Grant - ----------------------------------------------------------------------------------------------------- 1,314,503 Detectable Moelcules, Method of March 16, Preparation And Use 1993 Jannis Stavrianopoulos - ----------------------------------------------------------------------------------------------------- 1,314,810 Heterologous System for the March 23, Detection of Chemically-Labeled 1993 DNA and Other Biological Materials Providing a Receptor or Target Moiety Thereon Elazar Rabbani - ----------------------------------------------------------------------------------------------------- EP 0 242 527 B1 Analyte Detection by Means of May 13, 1992 Energy Transfer Jannis Stavrianopoulos et al. - ----------------------------------------------------------------------------------------------------- 1,315,222 Polynucleotide Probes and a March 30, Method for Their Preparation 1993 David Mao et al. - ----------------------------------------------------------------------------------------------------- 0 149 654 B1 Detecting Agent Carrying Polymer Sep. 9, 1992 Having Multiple Units of Visualization Monomer David C. Ward et al. - ----------------------------------------------------------------------------------------------------- EP 0 097 373 B1 Modified Nucleotides, Methods of Oct. 7, 1992 Preparing and Utilizing and Compositions Containing the Same Dean L. Engelhardt et al. - ----------------------------------------------------------------------------------------------------- EP 0 212 670 B1 Method for Detecting an Analyte Nov. 4, 1992 Moiety by Means of Signal Localization Elazar Rabbani - ----------------------------------------------------------------------------------------------------- EP 0 117 440 B1 Method and Structures Employing Apr. 7, 1993 Chemically-Labelled Polynucleotide Probes Jannis G. Stavrianopoulos et al. - ----------------------------------------------------------------------------------------------------- EP 0 244 860 B1 Polynucleotide Probes and a Apr. 7, 1993 Method for their Preparation David T. Mao et al. =====================================================================================================
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===================================================================================================== Patent Number Publication (Country) Title/Inventor Date of Patent Grant - ----------------------------------------------------------------------------------------------------- EP 0 343 424 B1 Method and Kit for Sample Apr. 21, 1993 Adherence to Test Substrate Huey-Lang Yang et al. - ----------------------------------------------------------------------------------------------------- EP 0 159 719 B1 Hybridization Method for the Jun. 30, 1993 Detection of Genetic Material Dean Engelhardt et al. - ----------------------------------------------------------------------------------------------------- EP 0 122 614 B1 Kit for Terminally Chemically Jul. 14, 1993 Labelling DNA Christine Brakel - ----------------------------------------------------------------------------------------------------- EP 0 150 844 B1 Method of Radioactively Labeling Jul. 28, 1993 Diagnostic and Therapeutic Agents Containing a Chelating Group Jannis Stavrianpoulos - ----------------------------------------------------------------------------------------------------- EP 0 237 737 B1 A Composition Specific for Sep. 8, 1993 Neisseria Gonorrhoea Andrew Lo et al. =====================================================================================================
The PRODUCTS listed in Exhibit B are covered by one or more patents of Enzo, including the patents listed above. This list may be updated quarterly at Enzo's discretion. -22- EXHIBIT B ENZO PRICE INDEX 1996
- ------------------------------------------------------------------------------------------------------------------- NONRADIOACTIVE LABELING OF NUCLEIC ACIDS - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price BIOPROBE(R) NICK TRANSLATION DNA LABELING SYSTEM Nick Translation Labeling Kits 42710-11 Nick Translation Kit with Bio-11-dUTP.....................................25 reactions $230.00 42710-12 Nick Translation Kit with Bio-16-dUTP.....................................25 reactions 230.00 42710-13 Nick Translation Kit with Bio-11-dCTP.....................................25 reactions 230.00 42710-14 Nick Translation Kit with Bio-7-dATP......................................25 reactions 230.00 42710-16 Nick Translation Kit with Fluorescein-12-dUTP.............................25 reactions 230.00 Nick Translation Deoxynucleotide Packs 42711 Bio-11-dUTP for Nick Translation..........................................25 reactions 140.00 42712 Bio-16-dUTP for Nick Translation..........................................25 reactions 140.00 42713 Bio-11-dCTP for Nick Translation..........................................25 reactions 140.00 42714 Bio-7-dATP for Nick Translation...........................................25 reactions 140.00 42716 Fluorescein-12-dUTP for Nick Translation..................................25 reactions 140.00 Nick Translation Reagent Pack 42710 Reagent Pack for Nick Translation.........................................25 reactions 105.00 BIOPROBE(R) RANDOM PRIMED DNA LABELING SYSTEM Random Primed Labeling Kits 42720-21 Random Primed Labeling Kit with Bio-11-dUTP...............................25 reactions 230.00 42720-22 Random Primed Labeling Kit with Bio-16-dUTP...............................25 reactions 230.00 42720-23 Random Primed Labeling Kit with Bio-11-dCTP...............................25 reactions 230.00 42720-24 Random Primed Labeling Kit with Bio-7-dATP................................25 reactions 230.00 42720-26 Random Primed Labeling Kit with Fluorescein-12-dUTP.......................25 reactions 230.00 Random Primed Deoxynucleotide Packs 42721 Bio-11-dUTP for Random Primed Labeling....................................25 reactions 140.00 42722 Bio-16-dUTP for Random Primed Labeling....................................25 reactions 140.00 42723 Bio-11-dCTP for Random Primed Labeling....................................25 reactions 140.00 42724 Bio-7-dATP for Random Primed Labeling.....................................25 reactions 140.00 42726 Fluorescein-12-dUTP for Random Primed Labeling............................25 reactions 140.00 Random Primed Labeling Reagent Pack 42720 Reagent Pack for Random Primed Labeling...................................25 reactions 105.00
- -------------------------------------------------------------------------------- NONRADIOACTIVE LABAELING OF NUCLEIC ACIDS
- ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price BIOPROBE(R) 3' OLIGONUCLEOTIDE LABELING SYSTEM 3' Oligo Labeling Kits 42730-31 3' Oligo Labeling Kit with Bio-16-ddUTP...................................25 reactions $315.00 42730-33 3' Oligo Labeling Kit with Fluorescein-12-ddUTP...........................25 reactions 315.00 3'Oligo Dideoxynucleotide Packs 42731 Bio-16-ddUTP for 3' Oligo Labeling........................................25 reactions 140.00 42733 Fluorescein-12-ddUTP for 3' Oligo Labeling................................25 reactions 140.00 3' OligoTailing Kits 42730-41 3' Oligo Tailing Kit with Bio-11-dUTP.....................................25 reactions 315.00 42730-42 3' Oligo Tailing Kit with Bio-16-dUTP.....................................25 reactions 315.00 42730-43 3' Oligo Tailing Kit with Bio-11-dCTP.....................................25 reactions 315.00 42730-44 3' Oligo Tailing Kit with Bio-7-dATP......................................25 reactions 315.00 42730-46 3' Oligo Tailing Kit with Fluorescein-12-dUTP.............................25 reactions 315.00 3'Oligo Deoxynucleotide Packs 42741 Bio-11-dUTP for 3' Oligo Tailing..........................................25 reactions 140.00 42742 Bio-16-dUTP for 3' Oligo Tailing..........................................25 reactions 140.00 42743 Bio-11-dCTP for 3' Oligo Tailing..........................................25 reactions 140.00 42744 Bio-7-dATP for 3' Oligo Tailing...........................................25 reactions 140.00 42746 Fluorescein-12-dUTP for 3' Oligo Tailing..................................25 reactions 140.00 OligoBridge(TM) Labeling Kits 42730-36 OligoBridge(TM)Labeling Kit.................................................25 reactions 315.00 OligoBridge(TM) Nucleotide Pack 42736 Nucleotide Pack for OligoBridge(TM)Labeling.................................25 reactions 140.00 Oligo Labeling Reagent Pack 42730 Reagent Pack for Oligonucleotide Labeling.................................25 reactions 190.00 BIOPROBE(R) RNA TRANSCRIPT LABELING SYSTEM RNA Labeling Kits 42750-51 RNA Labeling Kit with Bio-11-UTP..........................................20 reactions 330.00 42750-52 RNA Labeling Kit with Bio-16-UTP..........................................20 reactions 330.00 42750-53 RNA Labeling Kit with Bio-11-CTP..........................................20 reactions 330.00 42750-54 RNA Labeling Kit with Bio-17-ATP..........................................20 reactions 330.00 42750-56 RNA Labeling Kit with Fluorescein-12-UTP..................................20 reactions 330.00
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- ------------------------------------------------------------------------------------------------------------------- NONRADIOACTIVE LABAELING OF NUCLEIC ACIDS (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Ribonucleotide Packs 42751 Bio-11-UTP for RNA Labeling...............................................25 reactions $225.00 42752 Bio-16-UTP for RNA Labeling...............................................25 reactions 225.00 42733 Bio-11-CTP for RNA Labeling...............................................25 reactions 225.00 42754 Bio-17-ATP for RNA Labeling...............................................25 reactions 225.00 42756 Fluorescein-12-UTP for RNA Labeling.......................................25 reactions 225.00 RNA Labeling Reagent Pack 42720 Reagent Pack for RNA Labeling.............................................25 reactions 225.00 - ------------------------------------------------------------------------------------------------------------------- NUCLEOTIDES - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price DEOXYNUCLEOTIDES 42806 Bio-11-dUTP....................................................................50 nmol $285.00 42811 Bio-16-dUTP....................................................................50 nmol 285.00 42816 Bio-11-dCTP....................................................................50 nmol 285.00 42812 Bio-AP3-dCTP.................................................................22.5 nmol 230.00 42819 Bio-7-dATP.....................................................................50 nmol 285.00 42831 Fluorescein-12-dUTP............................................................25 nmol 140.00 42841 Rhodamine-dUTP.................................................................25 nmol 140.00 42851 Coumarin-dUTP..................................................................25 nmol 140.00 DIDEOXYNUCLEOTIDES 42813 Bio-16-ddUTP...................................................................25 nmol 140.00 42833 Fluorescein-12-ddUTP...........................................................25 nmol 140.00 RIBONUCLEOTIDES 42815 Bio-11-UTP....................................................................250 nmol 140.00 42814 Bio-16-UTP....................................................................250 nmol 140.00 42818 Bio-11-CTP....................................................................250 nmol 140.00 42817 Bio-17-ATP....................................................................250 nmol 140.00 42834 Fluorescein-12-UTP............................................................250 nmol 140.00 - ------------------------------------------------------------------------------------------------------------------- LABELING ACCESSORIES - GLASS FIBER FILTERS - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price 44524 Disc (24 mm diameter)..........................................................400/box $ 60.00 44525 Disc (25 mm diameter)..........................................................400/box 60.00 44101 Rectangle (10.25 cm x 25.4 cm).................................................100/box 120.00
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- ------------------------------------------------------------------------------------------------------------------- MEMBRANE HYBRIDIZATION AND DETECTION - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price MaxSense(TM) Membrane Hybridization Systems 45500 MaxSense(TM) BioProbe(R) Membrane Hybridization System (for DNA & RNA Probes) .........10 blots 10 x 10 cm each $135.00 45600 MaxSense(TM) OligoProbe Membrane Hybridization System (for Oligonucleotide Probes) ...10 blots 10 x 10 cm each 135.00 MaxSense(TM) Detection Systems 45401 BioDETEK(R)HP Hrp Membrane Detection System...................................1000 cm2 195.00 45402 BioDETEK(R)Alk Membrane Detection System......................................1000 cm2 195.00 45405 FluorDETEK(R)Hrp Membrane Detection System....................................1000 cm2 195.00 45406 FluorDETEK(R)AP Membrane Detection System.....................................1000 cm2 195.00 MaxSense(TM) BioProbe(R)Hybridization and Detection System Kits for DNA and RNA Probes Horseradish Peroxidase Detection System 45501 BioDETEK(R)HP Hrp Complete BioProbe(R)Membrane System..........10 blots 10 x 10 cm each 310.00 45505 FluorDETEK(R)Hrp Complete BioProbe(R)Membrane System...........10 blots 10 x 10 cm each 310.00 Alkaline Phosphatase Detection System 45502 BioDETEK(R)Alk Complete BioProbe(R)Membrane System.............10 blots 10 x 10 cm each 310.00 45506 FluorDETEK(R)AP Complete BioProbe(R)Membrane System............10 blots 10 x 10 cm each 310.00 MaxSense(TM) OligoProbe Hybridization and Detection System Kits for Oligonucleotide Probes Horseradish Peroxidase Detection System 45601 BioDETEK(R)HP Hrp Complete OligoProbe Membrane System..........10 blots 10 x 10 cm each 310.00 45605 FluorDETEK(R)Hrp Complete OligoProbe Membrane System...........10 blots 10 x 10 cm each 310.00 Alkaline Phosphatase Detection System 45602 BioDETEK(R)Alk Complete OligoProbe Membrane System.............10 blots 10 x 10 cm each 310.00 45606 FluorDETEK(R)AP Complete OligoProbe Membrane System............10 blots 10 x 10 cm each 310.00 MaxSense(TM) Hybridization and Detection System Accessories 45701 Hybridization Membrane..............................................roll, 30 cm x 3 m 225.00 45702 Hybridization Membrane........................................10 sheets, 15 cm x 10 cm 95.00 45703 Liquid Blocking Solution........................................................100 ml 50.00 45704 Liquid Blocking Reagent (concentrated)..........................................100 ml 80.00 45705 MaxSense(TM)BioProbe(R)Hybridization Buffer.....................................150 ml 50.00 45706 MaxSense(TM)OligoProbe Hybridization Buffer.....................................150 ml 50.00
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- ------------------------------------------------------------------------------------------------------------------- MEMBRANE HYBRIDIZATION AND DETECTION (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Dot Blot System 46305 Dot Blot Hybridization and Detection Assay Kit............................100 test kit $750.00 46305/C Dot Blot Control DNA Pack.......................................................1 pack 170.00 46307 Dot Blot CMV Control DNA Pack...................................................1 pack 135.00 46308 Dot Blot HBV Control DNA Pack...................................................1 pack 135.00 - ------------------------------------------------------------------------------------------------------------------- IN SITU HYBRIDIZATION ASSAY SYSTEMS - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Simply Sensitive Detection Systems 32830 Hrp - AEC System for in situ Detection.......................................20 slides $95.00 32840 Hrp - DAB System for in situ Detection......................................20 slides 95.00 32850 Fl-SA System for in situ Detection...........................................20 slides 95.00 32860 Alk Phos - INT / BCIP System for in situ Detection...........................20 slides 95.00 32870 Alk Phos - NBT / BCIP System for in situ Detection...........................20 slides 95.00 Ultrasensitive Enhanced Detection Systems 32300 Enhanced Hrp - AEC System for in situ Detection..............................30 slides 140.00 32400 Enhanced Hrp - DAB System for in situ Detection.............................30 slides 140.00 32500 Enhanced Fl -SA System for in situ Detection.................................30 slides 140.00 32600 Enhanced Alk Phos - INT / BCIP System for in situ Detection..................30 slides 140.00 32700 Enhanced Alk Phos - NBT / BCIP System for in situ Detection..................30 slides 140.00 Simply Sensitive - Horseradish Peroxidase - AEC Detection 32801-30 PathoGene(R)Assay for Adenovirus / Hrp - AEC..................................20 slides 235.00 32802-30 PathoGene(R)Assay for Cytomegalovirus / Hrp - AEC.............................20 slides 235.00 32803-30 PathoGene(R)Assay for Epstein-Barr Virus / Hrp - AEC..........................20 slides 235.00 32804-30 PathoGene(R)Assay for Hepatitis B Virus / Hrp - AEC...........................20 slides 235.00 32805-30 PathoGene(R)Assay for Herpes Simplex Virus / Hrp - AEC........................20 slides 235.00 32806-30 PathoGene(R)Assay for Chlamydia trachomatis / Hrp - AEC.......................20 slides 235.00 Simply Sensitive - Horseradish Peroxidase - DAB Detection 32801-40 PathoGene(R)Assay for Adenovirus / Hrp - DAB..................................20 slides 235.00 32802-40 PathoGene(R)Assay for Cytomegalovirus / Hrp - DAB.............................20 slides 235.00 32803-40 PathoGene(R)Assay for Epstein-Barr Virus / Hrp - DAB..........................20 slides 235.00 32804-40 PathoGene(R)Assay for Hepatitis B Virus / Hrp - DAB...........................20 slides 235.00 32805-40 PathoGene(R)Assay for Herpes Simplex Virus / Hrp - DAB........................20 slides 235.00 32806-40 PathoGene(R)Assay for Chlamydia trachomatis / Hrp - DAB.......................20 slides 235.00
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IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Simply Sensitive - Fluorescent Streptavidin Detection 32801-50 PathoGene(R)Assay for Adenovirus / Fl-SA......................................20 slides 235.00 32802-50 PathoGene(R)Assay for Cytomegalovirus / Fl-SA.................................20 slides 235.00 32803-50 PathoGene(R)Assay for Epstein-Barr Virus / Fl-SA..............................20 slides 235.00 32804-50 PathoGene(R)Assay for Hepatitis B Virus / Fl-SA...............................20 slides 235.00 32805-50 PathoGene(R)Assay for Herpes Simplex Virus / Fl-SA............................20 slides 235.00 32806-50 PathoGene(R)Assay for Chlamydia trachomatis / Fl-SA...........................20 slides 235.00 Simply Sensitive - Alkaline Phosphatase - INT / BCIP Detection 32801-60 PathoGene(R)Assay for Adenovirus / Alk Phos - NBT / BCIP.....................20 slides $235.00 32802-60 PathoGene(R)Assay for Cytomegalovirus / Alk Phos - NBT / BCIP................20 slides 235.00 32803-60 PathoGene(R)Assay for Epstein-Barr Virus / Alk Phos - NBT / BCIP.............20 slides 235.00 32804-60 PathoGene(R)Assay for Hepatitis B Virus / Alk Phos - NBT / BCIP..............20 slides 235.00 32805-60 PathoGene(R)Assay for Herpes Simplex Virus / Alk Phos - NBT / BCIP...........20 slides 235.00 32806-60 PathoGene(R)Assay for Chlamydia trachomatis / Alk Phos - NBT / BCIP..........20 slides 235.00 Simply Sensitive - Alkaline Phosphatase - NBT / BCIP Detection 32801-70 PathoGene(R)Assay for Adenovirus / Alk Phos - NBT / BCIP.....................20 slides 235.00 32802-70 PathoGene(R)Assay for Cytomegalovirus / Alk Phos - NBT / BCIP................20 slides 235.00 32803-70 PathoGene(R)Assay for Epstein-Barr Virus / Alk Phos - NBT / BCIP.............20 slides 235.00 32804-70 PathoGene(R)Assay for Hepatitis B Virus / Alk Phos - NBT / BCIP..............20 slides 235.00 32805-70 PathoGene(R)Assay for Herpes Simplex Virus / Alk Phos - NBT / BCIP...........20 slides 235.00 32806-70 PathoGene(R)Assay for Chlamydia trachomatis / Alk Phos - NBT / BCIP..........20 slides 235.00 Ultrasensitive Enhanced - Horseradish Peroxidase - AEC Detection 32801-33 PathoGene(R)Assay for Adenovirus / Enhanced Hrp - AEC .......................20 slides 290.00 32802-33 PathoGene(R)Assay for Cytomegalovirus / Enhanced Hrp - AEC...................20 slides 290.00 32803-33 PathoGene(R)Assay for Epstein-Barr Virus / Enhanced Hrp - AEC................20 slides 290.00 32804-33 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Hrp - AEC.................20 slides 290.00 32805-33 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Hrp - AEC..............20 slides 290.00 32806-33 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Hrp - AEC.............20 slides 290.00 Ultrasensitive Enhanced - Horseradish Peroxidase - DAB Detection 32801-44 PathoGene(R)Assay for Adenovirus / Enhanced Hrp - DAB........................20 slides 290.00 32802-44 PathoGene(R)Assay for Cytomegalovirus / Enhanced Hrp - DAB...................20 slides 290.00 32803-44 PathoGene(R)Assay for Epstein-Barr Virus / Enhanced Hrp - DAB................20 slides 290.00 32804-44 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Hrp - DAB.................20 slides 290.00 32805-44 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Hrp - DAB..............20 slides 290.00 32806-44 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Hrp - DAB.............20 slides 290.00
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IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Ultrasensitive Enhanced - Fluorescent Streptavidin Detection 32801-55 PathoGene(R)Assay for Adenovirus / Enhanced Fl -SA...........................20 slides 290.00 32802-55 PathoGene(R)Assay for Cytomegalovirus / Enhanced Fl -SA......................20 slides 290.00 32803-55 PathoGene(R)Assay for Epstein-Barr Virus / Enhanced Fl -SA...................20 slides 290.00 32804-55 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Fl -SA....................20 slides 290.00 32805-55 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Fl -SA.................20 slides 290.00 32806-55 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Fl -SA................20 slides 290.00 Ultrasensitive Enhanced - Alkaline Phosphatase - INT / BCIP Detection 32801-66 PathoGene(R)Assay for Adenovirus / Enhanced Alk Phos - INT / BCIP............20 slides 290.00 32802-66 PathoGene(R)Assay for Cytomegalovirus / Enhanced Alk Phos - INT / BCIP.......20 slides 290.00 32803-66 PathoGene(R)Assay for Epstein-Barr Virus / Enhanced Alk Phos - INT / BCIP....20 slides 290.00 32804-66 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Alk Phos - INT / BCIP.....20 slides 290.00 32805-66 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Alk Phos - INT / BCIP..20 slides 290.00 32806-66 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Alk Phos - INT / BCIP.20 slides 290.00 Ultrasensitive Enhanced - Alkaline Phosphatase - NBT / BCIP Detection 32801-77 PathoGene(R)Assay for Adenovirus / Enhanced Alk Phos - NBT / BCIP............20 slides $290.00 32802-77 PathoGene(R)Assay for Cytomegalovirus / Enhanced Alk Phos - NBT / BCIP.......20 slides 290.00 32803-77 PathoGene(R)Assay for Epstein-Barr Virus / Enhanced Alk Phos - NBT / BCIP....20 slides 290.00 32804-77 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Alk Phos - NBT / BCIP.....20 slides 290.00 32805-77 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Alk Phos - NBT / BCIP..20 slides 290.00 32806-77 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Alk Phos - NBT / BCIP.20 slides 290.00 PathoGene(R) Tissue Preparation Kit and Control Slides 32800 PathoGene(R)Tissue Preparation Kit........................................20 specimens 145.00 31871 Adenovirus Control Slide.......................................................1 slide 15.00 31872 Cytomegalovirus Control Slide..................................................1 slide 15.00 31873 Epstein-Barr Control Slide.....................................................1 slide 15.00 31875 Herpes Simplex Virus Control Slide.............................................1 slide 15.00 31876 Chlamydia trachomatis Control Slide............................................1 slide 15.00 31877 HPV 16 Probe Control Slide....................................................1 slide 15.00 ApopDETEK(R) in situ Cell Death Assay Systems 32930 ApopDETEK(R)in situ Cell Death Assay / Hrp - AEC..............................20 slides 175.00 32940 ApopDETEK(R)in situ Cell Death Assay / Hrp - DAB..............................20 slides 175.00 32950 ApopDETEK(R)in situ Cell Death Assay / Fl -SA.................................20 slides 175.00 32960 ApopDETEK(R)in situ Cell Death Assay / Alk Phos - INT / BCIP..................20 slides 175.00 32970 ApopDETEK(R)in situ Cell Death Assay / Alk Phos - NBT / BCIP..................20 slides 175.00
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- ------------------------------------------------------------------------------------------------------------------- IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Human Papillomavirus Identification Systems 32881 BioPap(R)Human Papillomavirus in situ Screening Assay for Cervical Smears...20 test kit 345.00 32892 BioPap(R)Human Papillomavirus in situ Typing Assay for Cervical Specimens (Types 6/11, 16/18 and 31/33/51)..................10 test kit 305.00 32883 BioPap(R)Human Papillomavirus in situ Typing Assay Cervical Specimen Transport Kit.................................for 10 specimens 35.00 32879 PathoGene(R)Human Papillomavirus in situ Screening Assay for Tissue Sections .....................................................20 test kit 425.00 32895 PathoGene(R) Human Papillomavirus in situ Typing Assay for Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................10 test kit 305.00 32877 PathoGene(R)Hrp-AEC Human Papillomavirus in situ Typing Assay fo r Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................20 test kit 525.00 32874 PathoGene(R)Hrp-DAB Human Papillomavirus in situ Typing Assay for Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................20 test kit 525.00 In Situ HYBRIDIZATION ASSAY ACCESSORIES Specimen Slides 31802-20 Pretreated slides / single well..............................................20 slides $25.00 31802-100 Pretreated slides / single well.............................................100 slides 85.00 31803-20 Pretreated slides / double well..............................................20 slides 25.00 31803-100 Pretreated slides / double well.............................................100 slides 85.00 Heating Blocks and Surface Thermometer 31500 Heating Block for use with 110V, 50/60 Hz.......................................1 unit 325.00 31508 Heating Block for use with 220V, 50 Hz..........................................1 unit 325.00 31580 Surface Thermometer.............................................................1 unit 30.00 Biological Reagents and Buffers 33801 Proteinase K..................................................................2 x 5 mg 30.00 33808 In situ Hybridization Buffer (1.25 X concentrate)................................10 ml 25.00 33809 In situ Hybridization Wash Reagent...............................................30 ml 25.00 33802 Enzo Wash Buffer Salts.........................................3 Packets, 1 liter each 15.00 33803 Enzo SignaSure(R)Wash Buffer...................................3 Packets, 1 liter each 25.00 33805 Dilution Buffer for Alkaline Phosphatase-linked Detection Reagents..............100 ml 30.00 33804 Dilution Buffer for Horseradish Peroxidase-linked Detection Reagents............100 ml 30.00 33806 Dilution Buffer for Fluorescence-linked Streptavidin............................100 ml 30.00 33807 Dilution Buffer for Double Antibody Enhancement Procedures......................100 ml 30.00
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- ------------------------------------------------------------------------------------------------------------------- BIOPROBE(R) LABELED PROBES - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Infectious Agents 40834 Adenovirus........................................................................2 ug $175.00 40835 Cytomegalovirus...................................................................2 ug 175.00 40836 Epstein-Barr Virus................................................................2 ug 175.00 40837 Hepatitis B Virus.................................................................2 ug 175.00 40838 Herpes Simples Virus..............................................................2 ug 175.00 40839 Chlamydia trachomatis.............................................................2 ug 175.00 40842 Hepatitis A Virus.................................................................2 ug 175.00 40843 Mycoplasma pneumonia..............................................................2 ug 175.00 40845 SV40..............................................................................2 ug 175.00 40846 Campylobacter jejuni..............................................................2 ug 175.00 40847 JC Virus..........................................................................2 ug 175.00 40848 BK Virus..........................................................................2 ug 175.00 Oncogenes 40714 c-Ha-ras..........................................................................2 ug 175.00 40717 c-Myc.............................................................................2 ug 175.00 40718 N-Myc.............................................................................2 ug 175.00 Hybridization Controls 40840 Lambda............................................................................2 ug 175.00 40849 Blur 8 (human alu repeat)........................................................2 ug 175.00 - ------------------------------------------------------------------------------------------------------------------- DETEK(R) SIGNAL GENERATING SYSTEMS - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Fluorescent Biotin Detection 43818 DETEK(R)f (Double Antibody Fuorescence Detection).......................for 200 slides $200.00 43821 DETEK(R)FS (Fluorescent Streptavidin Detection)..........................for 100 slides 110.00 DETEK(R) Colorimetric Signal Generating Systems 43820 DETEK(R)Hrp Kit (Hrp - AEC Detection).....................500 ml working solution or 150.00 ...........................................................40 membranes (100 cm2 each) 43840 FluorDETEK(R)Hrp Kit (Hrp - AEC Detection)................500 ml working solution or 150.00 ...........................................................40 membranes (100 cm2 each) 43822 DETEK(R)Alk Kit (Alk Phos- NBT/BCIP Detection)............500 ml working solution or 200.00 ...........................................................40 membranes (100 cm2 each) 43842 FluorDETEK(R)AP Kit (Alk Phos- NBT/BCIP Detection).........500 ml working solution or 200.00 ...........................................................40 membranes (100 cm2 each)
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- ------------------------------------------------------------------------------------------------------------------- DETEK(R) SIGNAL GENERATING SYSTEMS (continued) - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price Anti-Biotin Antibody Reagents 43823 DETEK(R)Enhancer Kit (Double Antibody Enhanced Detection).....................30 slides 125.00 43861 Rabbit anti-Biotin Antibody Concentrate........................400 ml working solution 210.00 Colorimetric Signal Generating Reagents 43825 AEC Substrate Kit..............................................300 ml working solution 90.00 43826 DAB Substrate Kit..............................................300 ml working solution 90.00 43827 NBT/BCIP Substrate Kit.........................................400 ml working solution 125.00 43828 INT /BCIP Substrate Kit........................................400 ml working solution 125.00 - ------------------------------------------------------------------------------------------------------------------- MICROPLATE HYBRIDIZATION ASSAYS - ------------------------------------------------------------------------------------------------------------------- Cat. No. Product Quantity Price 46330 HIV 1 Microplate Hybridization Assay.......................................96 test kit $625.00 46340 MTB Microplate Hybridization Assay.........................................96 test kit 625.00 46350 HBV (core antigen sequences) Microplate Hybridization Assay...............96 test kit 625.00 46360 HIV 2 Microplate Hybridization Assay.......................................96 test kit 625.00 46380 HBV (surface antigen sequences) Microplate Hybridization Assay.............96 test kit 625.00 46353 Enhanced Microplate Hybridization Assay for Hepatitis B....................96 test kit 700.00 46354 Enhanced Microplate Hybridization Assay for Hepatitis B Serum Titration Standards.....................4 runs 50.00 46331 Oligonucleotide Pair SK38/SK39..............................................2 x 5 nmol $175.00 46341 Oligonucleotide Pair MTB10/MTB11............................................2 x 5 nmol 175.00 46351 Oligonucleotide Pair HB01/HB02..............................................2 x 5 nmol 175.00 46355 Oligonucleotide Pair HB07/HB08..............................................2 x 5 nmol 175.00 46361 Oligonucleotide Pair VB306/VB310............................................2 x 5 nmol 175.00 46381 Oligonucleotide Pair HB011/HB014............................................2 x 5 nmol 175.00 46382 Oligonucleotide Pair HB012/HB013............................................2 x 5 nmol 175.00
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- ------------------------------------------------------------------------------------------------------------------- NONOCLONAL ANTIBODIES FOR IMMUNOPATHOLOGY - ------------------------------------------------------------------------------------------------------------------- Product Cat. No. Price Cat. No. Price Ready-to-Use for Concentrated for Format 6 ml Format 0.5 ml anti-Cytokeratin, 35(beta)H11, (low MW, 52.5 kd)........30902 $110.00 34902 $140.00 anti-Cytokeratin, 34(beta)E12 Keratin-903(TM) (high MW, 68, 58, 56.5, 50 kd)...............30903 110.00 34903 140.00 anti-Cytokeratin, 34(beta)B4, (high MW, 68 kd)..........30904 110.00 34904 140.00 anti-Melanoma, HMB45....................................30930 110.00 34930 140.00 anti-Muscle Actin, HHF35................................30931 110.00 34931 140.00 anti-Neuroendocrine, PHE5...............................30932 110.00 34932 140.00 anti-Smooth Muscle Actin, CGA7..........................30933 110.00 34933 140.00 anti-GFAP...............................................30934 110.00 34934 140.00 anti-Macrophage, HAM56..................................30935 110.00 34934 140.00
- 11 - EXHIBIT C Continuing Guaranty Baxter Healthcare Corporation Deerfield, Illinois 60015-4633 Vendor: Enzo Diagnostics, Inc. 60 Executive Blvd. Farmingdatel, NY 11735 1. Compliance with Laws: Vendor guarantees that each product shipped to, or on the order of, Baxter Healthcare Corporation or any affiliated corporation ("Baxter") is as of the date of shipment in compliance with all federal, state and local laws, regulations, rules and orders. Vendor specifically guarantees that: (Equal opportunity statement-required because Baxter is a government contractor) The products are not manufactured or sold in violation of any applicable Equal Employment Opportunity requirements, including those set forth in Section 202 of Executive Order 11246, as amended. 2. Insurance: Vendor agrees to procure and maintain general comprehensive liability insurance covering each occurrence of bodily injury and property damage in the amount of not less than One Million Dollars ($1,000,000) combined single limit (or such higher limits as Baxter shall reasonably request) with endorsements for product and completed operations, blanket contractual liability, and vendor's liability. Vendor shall on or before delivery of first PRODUCT, furnish a certificate of insurance evidencing the foregoing coverages and limits, stating that the insurer shall give Baxter written notice at least thirty (30) days prior to any cancellation, non-renewal or material change in coverage. At Baxter's request, Vendor will also provide assurance of such insurance. 3. Indemnification: Vendor agrees to indemnify and hold harmless Baxter from any liability, loss, expense, cost, claim or judgment, arising out of: a. (Products Liability) Any claim for property damage, or personal injury or death where the product is alleged to have caused or contributed to the damage, injury or death. This indemnification does not extent to injuries, damages or death to the extent caused by negligence on the part of Baxter or any of its employees or agents. b. (Patent infringement) Any claim that the products infringe the patent, trademark or other proprietary rights of any other party. 4. Recalls: Vendor agrees that it will reimburse Baxter for costs associated with product corrective actions (including recalls), except those recalls that result from Baxter negligence. 5. Survival of Guaranty: This guaranty shall be continuing and shall be binding upon the Vendor and his or its heirs, executors, administrators, successors and/or assigns and shall inure to the benefit of Baxter, its successors and assigns and to the benefit of its officers, directors, agents and employees. - 1 - Date: Corporate Seal Enzo Diagnostics, Inc. --------------------------------------------------------------- Corporate Name or Name Under Which Business is Conducted Attect: (If Corporation) --------------------------------------------------------------- Signataure & Title of Authorized Officer, Partner or Proprietor Secretary --------------------------------------------------------------- Printed Name & Title of Authorized Officer, Partner of Proprietor - 2 -