EXHIBIT 5.1

                                   May 28 2002


Enzo Biochem, Inc.
60 Executive Boulevard
Farmingdale, New York 11735


Gentlemen:

         You have requested our opinion with respect to the offer and sale by
you, Enzo Biochem, Inc., a New York corporation (the "Company"), pursuant to a
Registration Statement (the "Registration Statement") on Form S-8 under the
Securities Act of 1933, as amended (the "Act"), of up to 1,997,500 shares (the
"Shares") of common stock, par value $.01 per share, of the Company (the "Common
Stock"), issuable upon exercise of stock options (the "Options") available for
grant under the 1999 Employee Stock Option Plan.

         We have examined originals, or copies certified or otherwise identified
to our satisfaction, of such documents and corporate and public records as we
deem necessary as a basis for the opinion hereinafter expressed. With respect to
such examination, we have assumed the genuineness of all signatures appearing on
all documents presented to us as originals, and the conformity to the originals
of all documents presented to us as conformed or reproduced copies. Where
factual matters relevant to such opinion were not independently established, we
have relied upon certificates of executive officers and responsible employees
and agents of the Company.

         Based upon the foregoing, it is our opinion that the Shares have been
duly and validly authorized and when sold, paid for and issued as contemplated
by the Registration Statement and the Option will be duly and validly issued and
fully paid and nonassessable.

         We hereby consent to the use of this opinion as Exhibit 5.1 to the
Registration Statement. In giving this consent, we do not thereby concede that
we come within the categories of persons whose consent is required by the Act or
the General Rules and Regulations promulgated thereunder.



                                      Very truly yours,



                                      MORRISON COHEN SINGER & WEINSTEIN LLP




                                       7