FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Bench David
   2. Issuer Name and Ticker or Trading Symbol
ENZO BIOCHEM INC [ENZ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Financial Officer
(Last)
(First)
(Middle)
C/O ENZO BIOCHEM, INC., 527 MADISON AVENUE		 3. Date of Earliest Transaction (Month/Day/Year)
04/13/2022
(Street)

NEW YORK, NY 1002		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $0.01 Par Value (1) 04/14/2022   A   1,620 A $ 2.9 2,500 I By Trust (PSP)
Common Stock, $0.01 Par Value (1) 04/13/2022   A   880 A $ 2.9 880 I By Trust (PSP)
Common Stock, $0.01 Par Value (2)               4,138 I 401k

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (to acquire Common Stock) $ 2.98             03/24/2023(3) 03/24/2027 Common Stock 87,500   87,500 D  
Stock Option (to acquire Common Stock) $ 3.36             02/11/2023(3) 02/11/2027 Common Stock 87,500   87,500 D  
Stock Option (to acquire Common Stock) $ 2.63             01/11/2022(3) 01/11/2026 Common Stock 55,400   55,400 D  
Stock Option (to acquire Common Stock) $ 2.20             02/24/2021(3) 02/24/2025 Common Stock 55,400   55,400 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Bench David
C/O ENZO BIOCHEM, INC.
527 MADISON AVENUE
NEW YORK, NY 1002		       Chief Financial Officer  

Signatures

 /s/ David Bench   04/14/2022
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents shares held by David Bench Consulty Group, a profit sharing plan of which the reporting person is a participant.
(2) Represents restricted shares granted subject the Company's discretionary matching contribution and non-elective employer contribution which vest ratable over four years of service, which began on December 23, 2019.
(3) The stock options have a five-year term and will vest in three equal instalments, one on the first anniversary of the grant date, the second on the second anniversary of the grant date and the third on the third anniversary of the grant date.

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