BRYAN CAVE
                                 245 PARK AVENUE
                            NEW YORK, NEW YORK  10167

                                  June 13, 1995

Enzo Biochem, Inc.
60 Executive Boulevard
Farmingdale, New York  11735

Dear Sirs:

          We refer to the Registration Statement on Form S-3 filed by you with
the Securities and Exchange Commission relating to 494,928 shares of Common
Stock, $.01 par value per share (the "Shares"), of Enzo Biochem, Inc. (the
"Company").

          We have examined and are familiar with originals, or copies certified
or otherwise identified to our satisfaction, of such corporate records of the
Company, certificates of officers of the Company and of public officials and
such other documents as we have deemed appropriate as a basis for the opinions
expressed below.

          Based upon the foregoing, we are of the opinion that:

          1.   The Company is duly incorporated and existing under the laws of
               the State of New York;

          2.   The Shares, including those issuable upon exercise of the
               Warrants referred to in the Registration Statement of which this
               is an Exhibit, have been duly authorized; and

          3.   The Shares (including those issuable upon due exercise of the
               Warrants in accordance with their terms) being sold by the
               selling stockholders, when sold as contemplated in the
               Registration Statement, will be legally issued, fully paid and
               non-assessable.

          We hereby consent to the use of this opinion in the above-mentioned
Registration Statement and to the reference to our name under the heading "Legal
Opinions" in the Prospectus constituting a part of such Registration Statement.

                               Very truly yours,

                               BRYAN CAVE